Position 1
Project title: Role of DDX11, the Warsaw breakage syndrome DNA helicase, at the interface between chromosomal cohesion and replication
Supervisor: Francesca Pisani (francesca.pisani@ibbc.cnr.it)
Istituto di Biochimica e Biologia Cellulare – Consiglio Nazionale Ricerche (CNR), Naples, Italy
Keywords: molecular biology, gene editing, cell biology, protein/protein interaction analysis
Lab webpage: http://www.ibbc.cnr.it/researchers/francesca-maria-pisani/
Position 2
Project title: In vitro reconstitution of the de novo human cohesin loading pathway operating at the DNA replication fork
Supervisor: Castrese Morrone (castrese.morrone@ibbc.cnr.it)
Istituto di Biochimica e Biologia Cellulare – Consiglio Nazionale Ricerche (CNR), Naples, Italy
Keywords: molecular biology, correlative optical tweezers fluorescence microscopy for single-molecule studies, biochemistry
Lab webpage: http://www.ibbc.cnr.it/researchers/francesca-maria-pisani/
Position 3
Project title: Structural biology of DNA loop extrusion by cohesin
Supervisor: Jan Löwe (jyl@mrc-lmb.cam.ac.uk)
UKRI-MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Keywords: cryo-EM, in vitro reconstitution, biochemistry
Lab webpage: https://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/jan-lowe/
Position 4
Project title: Cohesin-mediated processes regulated by associated chromatin remodelling complexes
Supervisor: Dana Branzei (dana.branzei@ifom.eu)
IFOM ETS, Istituto Fondazione di Oncologia Molecolare, Milan, Italy
Keywords: cohesion, chromatin remodelers, cohesin dynamics, sister chromatid resolution, mitotic condensation
Lab webpage: https://www.ifom.eu/en/cancer-research/research-labs/research-lab-branzei.php
Position 5
Project title: In vivo imaging of cohesin-mediated loop extrusion during DNA double strand break repair
Supervisor: Gaëlle Legube (gaelle.legube@univ-tlse3.fr)
Centre de biologie intégrative – Centre National de la Recherche Scientifique (CNRS), Toulouse, France
Keywords: DSB repair, cohesin dynamics, live-cell imaging, Hi-C
Lab webpage: https://www.legubelab.com
Position 6
Project title: Novel regulators of sister chromatid cohesion
Supervisor: Raquel Oliveira (rcoliveira@igc.gulbenkian.pt)
Fundação Calouste Gulbenkian – Instituto Gubenkian de Ciência (FCG – IGC), Oeiras, Portugal
Keywords: mitosis, genetic screens, live-cell imaging analysis, cohesin regulators
Lab webpage: www.chromosomedynamicslab.com
Position 7
Project title: Molecular mechanisms that control DNA loop extrusion by cohesin
Supervisor: Jan-Michael Peters (Jan-Michael.Peters@imp.ac.at)
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Keywords: atomic force microscopy, biochemistry, biophysics, cohesin, CTCF, DNA loop extrusion, FRET, mechanism, MINFLUX, single-molecule imaging, cryo-EM
Lab webpage: https://www.imp.ac.at/groups/jan-michael-peters/
Position 8
Project title: Dynamic single-molecule studies of cohesin: using optical tweezers to analyse cohesin dynamics on single DNA molecules and single chromatin fibres
Supervisor: Mattijs De Groot (m.degroot@lumicks.com)
Lumicks B. V. (LUMICKS) Amsterdam, Netherlands
Keywords: single-molecule methods, optical tweezers, fluorescent microscopy, cell biology, molecular biology, biochemistry
Lab webpage: https://lumicks.com
Position 9
Project title: Cohesin (mal)functioning in cohesinopathies
Supervisor: Job de Lange (j.delange1@amsterdamumc.nl)
Amsterdam University Medical Centers (VUMC), Amsterdam, Netherlands
Keywords: cohesinopathies, gene editing, disease modeling
Lab webpage: https://www.amsterdamumc.org/en/research/researchers/job-de-lange.htm
Position 10
Project title: Roles of newly discovered DNA replication and transcription regulatory genes essential for survival of ESCO2 and DDX11 deficient cells
Supervisor: Rob Wolthuis (r.wolthuis@amsterdamumc.nl)
Amsterdam University Medical Centers (VUMC), Amsterdam, Netherlands
Keywords: DNA replication, gene transcription, cohesin biology
Lab webpage: https://www.amsterdamumc.org/en/research/researchers/rob-wolthuis.htm
Position 11
Project title: Development of stem cell-based models of cohesinopathies in vitro
Supervisor: Marina Tarunina (marina@plasticell.co.uk)
Plasticell Ltd (PLASTICELL), Stevenage, United Kingdom
Keywords: induced-pluripotent stem cells, cell differentiation mechanisms; cohesinopathies; disease modeling, CombiCult® platform
Lab webpage: http://www.plasticell.co.uk
Position 12
Project title: Crosstalk of cohesin and Polycomb in differentiated and cancer cells
Supervisor: Ana Losada (alosada@cnio.es)
Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
Keywords: 3D genome organization, (epi)genomics, molecular biology